Resistencia a la insulina / Diabetes

Es una prueba en sangre que mide la resistencia a insulina y permite identificar con precisión quellos sujetos en riesgo de presentar prediabetes y diabetes mediante un reporte de  biomarcadores metabolómicos no glicémicos, antges que la HbA1c.

Analiza tres metabolitos involucrados en las vías metabólicas de ácidos grasos. Así como la detección oportuna de un proceso metabólico que antecede a la diabetes tipo 2 para prevención.

Conozca y descargue los trabajos científicos referentes a esta prueba:

A Novel Fasting Blood Test for Insulin Resistance and Prediabetes.

Insulin Resistance A Multifaceted Syndrome Responsible for NIDDM, Obesity, Hypertension, Dyslipidemia, and Atherosclerotic Cardiovascular Disease.

Early Metabolic Markers of the Development of Dysglycemia and Type 2 Diabetes and Their Physiological Significance.

Insulin Resistance as a Predictor of Age-Related Diseases.

a-Hydroxybutyrate Is an Early Biomarker of Insulin Resistance and Glucose Intolerance in a Nondiabetic Population.

Effect of Insulin Resistance, Dyslipidemia, and Intra-abdominal Adiposity on the Development of Cardiovascular Disease and Diabetes Mellitus.

 Diabetes 1 Prediabetes: a high-risk state for diabetes development.

 A Novel Insulin Resistance Index to Monitor Changes in Insulin Sensitivity and Glucose Tolerance: the ACT NOW Study

Análisis de sangre específico para la detección de la hiperglucemia reciente, aprobado porla FDA.

Ayuda a reportar o revelar las tendencias recientes de los picos postprandiales de glucosa, lo que evidencia mejoría o falta de control en el paciente con diabetes.

Conozca y descargue los trabajos científicos referentes a esta prueba:

 Effect of 1,5-anhydroglucitol levels on culprit plaque rupture in diabetic patients with acute coronary syndrome

 Circulating 1,5-Anhydroglucitol Levels in Adult Patients With Diabetes Reflect Longitudinal Changes of Glycemia

 Evaluation of an assay for serum 1,5-anhydroglucitol (GlycoMarkk) and determination of reference intervals on the Hitachi 917 analyzer

 Plasma anhydro-D-glucitol (1,5-AG) as an indicator of hyperglycaemic excursions in pregnant women with diabetes

 1,5-Anhydroglucitol and Postprandial Hyperglycemia as Measured by Continuous Glucose Monitoring System in Moderately Controlled Patients With Diabetes

 Association of 1,5-anhydroglucitol with cardiovascular disease and mortality

 Low 1,5-anhydroglucitol levels are associated with long-term cardiac mortality in acute coronary syndrome patients with hemoglobin A1c levels less than 7.0%

 Measurement of 1,5-anhydroglucitol in blood and saliva: from non-targeted metabolomics to biochemical assay

Plasma 1,5-Anhydro-D-Glucitol as New Clinical Marker of Glycemic Control in NIDDM Patients

1,5-Anhydro-D-Glucitol Evaluates Daily Glycemic Excursion in Well-Controlled NIDDM

Clinical usefulness of serum 1,5-anhydroglucitol in monitoring glycaemic control

Serum 1,5-Anhydro-D-Glucitol (Glycomark™):A Short-Therm Glycemic Marker

Effect of canagliflozin, a sodium–glucose cotransporter 2 inhibitor, on measurement of serum 1,5-anhydroglucitol*

The Use of 1.5-Anhydroglucitol for Monitoring Glycemic Control in Islet Transplant Recipients

Clinical Application of 1,5-Anhydroglucitol Measurements in Patients with Hepatocyte Nuclear Factor-1α Maturity-Onset Diabetes of the Young

ADA SGLT2i poster

1,5-AG Good SGLT2 Treatment Predictor 2020

Es una prueba de sangre que evalúa el riesgo genético de padecer diabetes tipo 2 y obesidad para la intervensión temprana.

Evalúa el riesgo de diabetes tipo 2, analizando 16 polimorfismos en 16 genes.

Conozca y descargue los trabajos científicos referentes a esta prueba:

Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.

Association of a Low-Frequency Variant in HNF1A With Type 2 Diabetes in a Latino Population.

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility.

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus

Haplotypes of Transcription Factor 7–Like 2 (TCF7L2) Gene and Its Upstream Region Are Associated With Type 2 Diabetes and Age of Onset in Mexican Americans

ADCY5 Couples Glucose to Insulin Secretion in Human Islets

Infuence of obesity, parental history of diabetes, and genes in type 2 diabetes: A case-control study.

Adaptive Human CDKAL1 Variants Underlie Hormonal Response Variations at the Enteroinsular Axis.

Investigation of Type 2 Diabetes Risk Alleles Support CDKN2A/B, CDKAL1, and TCF7L2 As Susceptibility Genes in a Han Chinese Cohort.

Type 2 Diabetes Variants Disrupt Function of SLC16A11 through Two Distinct Mechanisms

Examination of All Type 2 Diabetes GWAS Loci Reveals HHEX-IDE as a Locus Influencing Pediatric BMI

Autoimmunity against INS-IGF2 Protein Expressed in Human Pancreatic Islets*

Identification of a New Autoantigen in Type 1 Diabetes

Es una prueba que analiza el riesgo genético de padever diabetes gestacional y alteraciones en el metabolismo del ácido fólico y homociteína.

Analiza 20 polimorfismos que ayudan a evitar complicaciones durante el embarazo, como daños del tubo neural y diabetes gestacional.

Conozca y descargue los trabajos científicos referentes a esta prueba:

Watanabe Genome Medicine 2011 

 Van der Put NM et al. A second common mutation in the methylenetetrahydrofolate reductase gene

 Stover, P.J. Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies

 Servy, E.J. et al. MTHFR isoform carriers. 5 MTHF (5 methyl tetrahydrofolate) vs folic acid

 Salbaum, J.M. & Kappen, C. Genetic and Epigenomic Footprints of Folate

 Xenbiotica _Scaglione2014

Comunicado_Póster Matergen

Refsum, H. et al. The Hordaland Homocysteine Study

Polymorphisms of methylenetetrahydrofolate reductase and other enzymes

Common Polymorphisms That Affect Folate Transport or Metabolism Modify the Effect of the MTHFR 677C

Cao, Y. et al. The association of idiopathic recurrent early pregnancy loss with polymorphisms in folic acid metabolism-related genes

ABCC8 and TCF7L2 polymorphisms and the response to sulfonylurea treatment in patients wirth type 2 diabetes

Whetstine, J.R. et al. Single nucleotide polymorphisms in the human reduced folate carrier

PATIA GDM_ADA2022